We study lens physiology, the physiology of aqueous humor dynamics and regulation of Na,K-ATPase activity. We have been interested in the mechanistic role of Src tyrosine kinase signaling, TRPV1 and TRPV4 ion channels, and connexin hemichannels. Mechanosensitive ion channels seem to be very important. Recently we have become intrigued by piezo1 and TRPM3 channels. Mutation of TRPM3 is associated with early onset cataract in humans.